Please note that this section reports on claims that have NOT yet been substantiated through scientific studies.
Besides removing ammonia from the body, citrulline is believed to stimulate the immune system and increase energy levels. However, preliminary clinical research has indicated that citrulline does not improve exercise performance. Citruline has also been claimed to reduce neutrophilia and symptoms in patients with sickle cell disease.
Amino acids (AAs) are available as individual AAs or in proprietary AA combinations, as well as part of multi-vitamin formulas, proteins, and food supplements. The forms include tablets, fluids, and powders. However, adequate protein in the diet should provide a sufficient source of all amino acids.
There are no conditions that increase the nutritional requirements for citrulline.
Side effects, toxicity, and interaction
The use of a single amino acid supplement may lead to negative nitrogen balance, decreasing the metabolic efficiency and increasing the workload of the kidneys. In children, taking single amino acid supplements may also harmfully affect growth parameters.
Always avoid taking individual amino acids in high dosage for prolonged periods.
Women who are pregnant or breastfeeding should not use citrulline supplements.
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